New tablets will not allow cancer cells to “treat themselves”

Cancers are not in the least dangerous, in that they are extremely stable and have a high ability to heal itself even after a very severe damage. But what if you deprive cancer cells of this “bonus”? This approach would make them less resistant to treatment. And that such method was developed by scientists from Britain, creating a new drug in pill form.

New drug, developed jointly by researchers from the Institute of Francis Crick and Oxford University, aims to found in tumor cells vulnerability. The fact that some types of cancer (particularly cancer of the majority of the intestine) develops due to the lack of a particular protein AhR — Aryl hydrocarbon Receptor (arrowy hydrocarbon receptor). And to replace it is quite suitable substance I3C — Indole-3-Carbinol (indole-3-carbinol). According to one of the authors, Dr. Amina, Meiji,

“We examined mice that cannot produce or activate the AhR in the intestinal tract, and found that they can easily developing inflammation of the intestine that progresses to cancer. But if in their diet to add I3C, inflammation and cancer does not develop. Moreover, even the translation of cancer patients mice on the diet with I3C causes a decrease in malignancy and reducing the size of the tumors, making them less resistant to traditional therapies.”

After the “replacement” of one other protein decreases the ability of tumor cells to self-regeneration and increases the vulnerability and permeability of cell membranes. Thus, the tumor becomes more vulnerable to radio – and chemotherapy, which leads to the fact that you can either get smaller doses, which will lead to less damage to healthy tissue, or to the fact that the same dose of treatment will be more effective.

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