CRISPR is it safe 100 percent? Scientists say no, but offer solutions

Genome editing with CRISPR-Cas9 is not only a promising tool for research, but the key to developing new treatments, as we reported a few days ago. But is there a danger in the application of CRISPR? This question was asked and scientists from the University clinic Charite Berlin University and came to the conclusion that the danger is still there, but they immediately told and how it can be avoided.

As reported in the publication Nature Medicine, German scientists in the study of genetic material, edited by CRISPR-Cas9, discovered that in some cases it can cause the development of autoimmune reactions. And the cause just the protein Cas9. As explained by the authors,

“Cas9 is a protein obtained from bacteria of Streptococcus and it is today an integral part of the CRISPR-Cas9. Since streptococcal infections are common in humans, we hypothesized that the immune system may in certain cases recognize it as alien.”

After a series of tests, scientists have found that immune T cells that react to proteins Cas, was found in almost all healthy subjects.

“These types of immune cells can cause the development of undesired autoimmune reactions during gene therapy. Of course, the chance of this is not high, but it is still there. And it will potentially decrease the safety and effectiveness of the technology.”

But scientists do not just consider the possible side effects of gene therapy, but have developed a special test that will reveal will a person to develop an immune response or not. Together with their colleagues from the Berlin Center of Advanced methods of treatment experts have created a technology that allows you to produce a fence of T-cells in patients to conduct their tests on compatibility.

In addition, the developed method of isolation of T-cells in the case that there is a risk of an immune response. Initial clinical trials of this technology have been used in patients undergoing transplantation of kidneys and bone marrow and showed positive results.

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