Created a cure that “sets” the body to fight cancer

Modern pharmacological industry has already created a huge amount of drugs. However, as we know, our body has, so to speak, “built-in” system to deal with different pathologies. This system is called “immunity”. And he is capable of much. Even if his features seem less obvious. For example, not so long ago a group of researchers from Yale University have created a substance that rebuilds the immune system so that the latter destroyed the cancer cells.

It turns out that the immune system can defeat cancer. She needed only a little help

How to cope with cancer?

As reported on the website of the University, the research team, led by school staff Akiko Iwasaki and Anna Pyle, studied whether the synthetic RNA molecule, designed to fight viruses, also induce an immune response against tumors. The molecule, called Stem Loop RNA 14 (SLR14), was specifically designed to activate the gene that detects viruses and other threats in the cells.

Our idea is to mimic a viral infection within the tumor, tricking the immune system. This will force her to pay attention to the “infection” and destroy it, simultaneously destroying and cancer. says Akiko Iwasaki.

To test this theory the researchers conducted a series of experiments. They introduced SLR14 directly to tumors in mice and observed the process of destruction of cancer T-cells of the immune system. Thus the introduction of molecules in one place also stimulated T cells in order to begin to work in another area of the body affected by the cancer. On our portal we often write about this kind of survey, so if you are interested in this topic, then subscribe to our news channel in the Telegram.

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In another experiment, the scientists simulated a metastasis of cancer, disseminating tumor cells throughout the body. Scientists have introduced them through the left ventricle of the heart of rodents to explode the cells in the greatest possible number of bodies. Yes, it sounds very humane, but otherwise to test the hypothesis, unfortunately, simply will not work. The results showed that the therapy SLR14 in metastasized tumors is also effective.

Further study of the action of the drug showed that SLR14 comparable in its efficacy with existing drugs for cancer immunotherapy and may enhance their antitumor response. Experts from Yale University also found that “memory” of the immune system which was stimulated by this therapy, also protects against recurrence of tumor formation in the future and even gives the possibility of destroying the cancer in the early stages of the origin of the neoplastic process.

We have to use the immune system to find the tumor and kill them before they turn into cancer. — says Anna Pyle.

The next step in the study of the drug is the testing of this method of therapy as independent. The scientists also want to test its effectiveness in combination with other treatment options like radiation or chemotherapy. In addition, the researchers also focused on conducting experiments involving human volunteers.

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