Born first in the history of macaques-rhesus sperm from frozen testicular

A procedure that involves the removal and freezing of immature testicular tissue with the subsequent implantation, led to the first live birth of a healthy monkey. This technique can theoretically help the boys goubernator period, facing treatment for cancer: 30% of them become infertile because of the sharp effects of chemotherapy and radiation. Currently, these boys have no choice, which would allow them to guarantee the biological children in the future.

Doctors can freeze the sperm of adult male patients, but boys begin to produce Mature sex cells only upon reaching sexual maturity. At this point, hormonal changes in the body increase testosterone levels, stimulating the development of stem cells in the testes to semen. Chemotherapy and radiation therapy can Deplete these stem cells, which leads to low sperm and infertility.

Is it possible to freeze the sperm in the testes?

In the new study, scientists from Medical school of Universitet of Pittsburgh and his colleagues surgically removed and frozen testicular tissue in five young rhesus monkeys who were too young to produce sperm. Then the monkeys were castrated to ensure that they are sterile. When the monkey has reached sexual maturity, the frozen tissue thawed and transplanted under the scrotum of the same animal from which they were taken originally.

After 8-12 months, the scientists collected tissue from the site of transplantation and drew from it a sperm in the laboratory. In a fabric produced enough sperm to fertilize 138 of the eggs. Of those, only 16 turned into embryos suitable for implantation. The researchers moved 11 of these embryos into female macaques, which led to a pregnancy and subsequent birth alive. The results were published in Science.

“In the beginning of the experiment, we grafted tissue with zero sperm, and when collected the grafts they produced millions and millions of sperm,” says Kyle Orwig, senior author of the study and Professor of obstetrics, gynecology and reproductive science at the University of Pittsburgh. “We are confident that if the same thing will happen with human tissues, we will have more than enough sperm to fertilize the egg and conceive”.

As for the low yield of embryos, Orvig saying the procedure has affected the sperm quality, and possibly other factors such as the quality of eggs and breeding. Monkeys usually breed from October to may. The first two experiments, which held Orwig and his team were at the end and the beginning of the breeding season, and no attempt has not led to pregnancy. The third attempt in November 2017, has led to the birth of a healthy female monkey in April last year.

Once again animal experiments give a chance for a healthier and more complete human life. I agree with this approach? Tell us in our chat.

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